Complementary projects
Several projects complementary to the Epipage 2 study are being conducted among subgroups of the cohort. Additional investigations were performed to meet the particular objectives of these projects.
The recruitment of these subgroups took place in centers that volunteered to participate in these studies. The staff recruiting subjects provided specific information about them to the families before asking them if they were willing to participate.
All these complementary projects can use all of the cohort data collected at recruitment and during follow-up.
Recruitment for some of these projects continued beyond December 31, 2011, to include a large enough number of subjects.
Principal investigator: Pr Elie SALIBA, UCH Tours Despite progress in the survival of very preterm children, their neurological development remains worrisome. These children are at greater risk than others of behavioral problems and learning disorders, which may be explained by disorders in executive functions (cerebral functions that allow individuals to adapt their behavior to changes in their environment) that are manifested by difficulties in problem solving and in working memory. This study includes 581 children. Principal investigator: Pr Pascal BOILEAU, IHC Poissy-St-Germain Although the survival of preterm children has increased in recent years, the complication rates associated with very preterm birth remain high (40% have respiratory complications, 20% infectious complications, and 40% cerebral complications) and are associated with a high risk of disabilities (40%). The issue for the years to come is to reduce the frequency of these complications by implementing prevention strategies. Principal investigator: Pr Alexandre LAPILLONNE, Necker Hospital, Paris French studies have recently suggested that preterm children's diets may be a decisive factor for their outcome. Accordingly, the quantity of milk received in the first weeks of life, its origin, its composition, and additional lipid and iron intake are factors that might significantly influence neurological outcome in children born before 33 weeks of gestation. The objective of this study is to study the influence of the quantity and composition of the milk received in the first weeks of life on neurological outcome at the age of 2 years. This study includes 329 children. To find out more about EPINUTRI study, click here The self-administered questionnaire for the EPINUTRI study supplemented the questionnaire sent to parents as part of Epipage 2 and collected information about breastfeeding between 6 and 12 months, consumption of fish and egg yolks (sources of DHA intake), and possible iron supplementation. This questionnaire was not available online, but was mailed to parents. Intestinal ecosystem of very and extremely preterm infants: Analysis of the microbiota and its short- and long-term clinical implications Principal investigator: Pr Marie-José BUTEL, Paris Descartes University Associated group: MICALIS, INRA, Jouy-en-Josas Studies have shown that development of the gut flora (all the microorganisms present in the intestines) during the first weeks of preterm babies' lives is aberrant and may affect the child's health in both the short term (intestinal complications during the initial hospitalization) and the long term (obesity, diabetes, allergies, etc.). This study examines: This study includes 731 children. Observation of the Mother-Preterm Baby Bond Recent data about child development suggest that the establishment of the mother-child bond can influence the quality of the child's growth (height and weight), motor progress (development and coordination of movements), and intellectual and language development. In preterm births, the negative experiences around the birth, by including particular mother-child interactions, may have a durable influence on the child's outcome. The objectives of this study are: This study includes 192 children. Palliative care decisions and practices around extremely preterm birth: role of the healthcare professionals and involvement of parents Principal investigator: Dr Laurence FOIX L'HELIAS, GH Armand Trousseau-La Roche Gouyon Extremely preterm children, born between 22 and 26 weeks of gestation, account for 0.2 to 0.3% of births and require particular care. This care varies from one country to another and even from one hospital to another. Depending on their gestational age, their birth weight, and other criteria often associated with medical staff, some receive intensive care, while others do not. . The objectives of this study are to: This study includes 430 births. Epidemiology of painful procedures in the NIC
Principal investigator: Pr Ricardo CARBAJAL, GH Armand Trousseau-La Roche Guyon
In France, the EPIPPAIN study performed in 2005-2006 in 13 NICUs in the Ile-de-France region showed that such procedures are performed extremely frequently in newborns admitted in the NICU, and that the use of methods for managing pain varied highly between the units. The objectives of this second phase of EPIPPAIN are to: This study includes 592 children. Among these 592 newborns, 332 are also participating in Epipage 2. Epirmex
The objective of this study is to investigate, at the age of 3 years, during a specific examination set up as part of this project, the appearance of impairments in executive functions in these children and its relation to structural brain aberrations observed during magnetic resonance imaging (MRI) performed at birth.
One specific 3-year follow-up stage is ongoing to collect informations about children neurodevelopment.Biopag
As part of this study, samples of cord blood and maternal blood were taken at birth. The results of the genetic analyses of these blood samples will be combined with the child's health data collected at birth and during the Epipage 2 follow-up, to examine whether early modifications of some genes may be associated with and, possibly, predict specific complications of very preterm birth.
This study includes 145 children.Epinutri
Specific follow-up of children at 1 year - Practical procedures
Epiflore
One specific 3-year follow-up stage is ongoing using a parental self-administered questionnaire and a collect of faeces sample.Olimpe
Principal investigator: Dr Jean-Baptiste MULLER, UCH Nantes
Chorhist
Principal investigators: Pr Gilles KAYEM, UCH Louis-Mourier, AP-HP, Colombes
Pr Damien SUBTIL, UHC Lille
This study included 1406 births and enabled specific data collection for 1360 placentas.
To find out more about CHORHIST study, click hereEthics
Epippain 2
Epilang
Epiremed
Epivarec