Follow-up at 5½ years of age

The third stage of follow-up, at the age of 5½ years, began in September 2016 and continued through December 2017.

For this stage, families were invited to a study-specific health examination, visiting a doctor and a neuropsychologist. At the same time, data were collected from parents, by a self-administered questionnaire similar to those they received for the first two stages of follow-up.


Number of subjects

All families included in the follow-up at age 2 years were invited to participate in this new stage, unless they had previously stated that they refused future participation.

Overall, questionnaires were sent to the families of 4419 children in the Epipage 2 cohort.

A group of children born at term (between 37   and 40 weeks) ) were also invited to participate in this follow-up, that is, 600 children in the Elfe cohort (French longitudinal survey from childhood) which is essentially contemporaneous with Epipage 2. which is essentially contemporaneous with Epipage 2.

Finally, the children born at term and included in the EPIPPAIN 2 study

Data collected

The health examination took place in two parts, in one or more half-days:

- a consultation with a doctor, lasting approximately 1 hour

- a meeting with a neuropsychologist, which took around 2 hours

The doctors measured the children's height and weight and assessed their vision, hearing, and global development. They also performed several tests to detect potential motor difficulties. Finally, some parents were asked to take a small saliva sample from their child.

The neuropsychologist used games (naming images, drawing lines, putting puzzles together) to assess children's global behavior and their aptitude to understand and memorize simple instructions.

Parents received a self-administered questionnaire asking for information about the children's health status, quality of life, and global development, but also about the parents' well-being.

Q parents 5 ans


Data collection procedures

The regional study coordinator contacted parents shortly before their child turned 5½ to describe this new stage of follow-up and offer them an appointment for this free Epipage 2 health examination.

The examination was free, and they received a gift certificate in the amount of € 50 when it was finished.

Parents also received the self-administered questionnaire the day of the examination. It could also be completed online (by internet) using the child's health records and the access codes (identifier/password) they received by email and/or regular mail.

For the children whose parents could not take them to an Epipage 2 follow-up center, including parents living in Martinique, this follow-up was conducted by a postal mail questionnaire.


Epipage 2 follow-up centers and current status

The Epipage 2 examination was organized in the centers listed on this map of France. Parents could choose the center most convenient for them.  
This follow-up for children aged 5½ was completed by the end of 2017. The families of 3404 children agreed to participate in this new follow-up stage, that is, 78% of the eligible population. Among them, 2 959 underwent the complete work-up (medical and neuropsychological examinations). 407children participated in the streamlined version, with only the self-administered questionnaire completed by parents. 592 children born at term and participating in the Elfe cohort also agreed to participate in this stage and thus served as a "control group" for the Epipage 2 cohort.

children born at term and participating in the Elfe cohort also agreed to participate in this stage and thus served as a "control group" for the Epipage 2 cohort.

logos regions Nord-Pas de Calais Picardie Haute-Normandie Champagne-Ardennes Lorraine Alsace Basse-Normandie Centre Ile-de-France Bretagne Bourgogne Franche Comté Pays de Loire Poitou-Charentes Limousin Auvergne Rhône-Alpes Aquitaine Midi-Pyrennées Languedoc Roussillon PACA Corse Guadeloupe Réunion Martinique Guyane


number of children : 116

CHU de Montpellier - CAMSP (34)
CHU de Nîmes (30)
CH de Carcassonne (11)
CH de Perpignan - CAMSP ADPEP (66)


number of children : 101

CHRU de Strasbourg (67)
CH de Colmar (68)
CH de Mulhouse (68)
CH de Haguenau (67)


number of children : 126

CHU de Bordeaux (33)
CH de La Côte Basque - Bayonne (64)
CH de Pau (64)
CH d'Agen (47)
CH de Mont de Marsan (40)
CH de Périgueux - CAMSP (24)


number of children: 34

CHU Estaing - Clermont-Ferrand (63)
CAMSP Rezo de Brioude (43)
CAMSP d'Espaly Saint Marcel (43)



number of children: 78

CHU de Caen (14)


number of children: 71

CHU de Dijon (21)
CH William Morey - Chalon sur Saône (71)
CH de Mâcon (71)


number of children: 363

Hôpital de La Croix Rousse - Réseau ECL'AUR AURORE - Lyon (69)
Hôpital Femme, Mère, Enfant - Réseau ECL'AUR AURORE - Bron (69)
CH de Villefranche sur Saône - Réseau ECL'AUR AURORE (69)
CH de Bourg en Bresse - Réseau ECL'AUR AURORE (01)
CH de Valence (26) - Réseau ECL'AUR AURORE
CH Métropole Savoie - Réseau RP2S - Chambéry (73)
CH Alpes Léman - Réseau RP2S (74)
CH Annecy Genevois - Réseau RP2S (74)
CHU de Grenoble - Réseau Naître et Devenir (38)
CHU de Saint Etienne - Réseau ELENA (42)


number of children: 89

CHRU de Tours (37)
CHR d'Orléans (45)


number of children: 46

CHU de Pointe à Pitre (97)
CAMSP de Basse Terre (97)


number of children: 24

Hôpital Mère-enfant de Limoges (87)


number of children: 95

CHRU de Nancy (54)
Hôpital de Mercy - Metz (57)
Hôpital de Forbach (57)


number of children: 12

Pas de centre, suivi par questionnaire postal


number of children: 137

CHU de Toulouse - Hôpital des enfants (31)
Clinique Ambroise Paré - Toulouse (31)
CAMSP d'Auch (32)
CH de Bigorre - Tarbes (65)
CAMSP d'Albi (82)
CH de Montauban (82)
CAMSP L'escabelle - Montauban (82)
CH de Cahors (46)
CMPP de Cahors (46)
CH de Castres (81)
CH de Rodez (12)


number of children: 324

CHRU de Lille - Hôpital Jeanne de Flandre (59)
Hôpital Saint Vincent de Paul - Groupement des hôpitaux de l'institut catholique de Lille (59)
CH de Valenciennes (59)
CH de Maubeuge (59)
CH de Calais (62)
CH d'Arras (62)
CH de Lens (62)
CH de Roubaix (59)
CH de Douai (59)


nnumber of children: 127

CHU de Reims - CAMSP (51)
CAMSP de Troyes (10)
CAMSP de Charleville Mezieres (08)


number of children: 30

CH André Rosemon - Cayenne (97)
CH de l'Ouest Guyanais - Saint Laurent du Maroni (97)

PACA et Corse

number of children: 252

Hôpital La Conception AP-HM - Marseille (13)
Hôpital Nord AP-HM - Marseille (13)
Hôpital l'Archet - Nice (06)


number of children: 77

CHR Sud Réunion - Saint Pierre (97)
CAMSP Nord Sainte-Clotilde - Saint Denis (97)


number of children: 133

CHU de Rennes - CAMSP (35)
CHU de Brest (29)
CH de Vannes (56)
CAMPS Eclore - Lorient (56)
Réseau ADEPAFIN - Saint Brieuc (22)


number of children: 69

CHU d'Amiens (80)
CH de Beauvais (60)
CH de Creil (60)
CH de Compiègne (60)
CH de Saint Quentin (02)
CH de Laon - CAMSP (02)


number of children: 102

CHU de Rouen (76)
Hôpital Jacques Monod - GHH Le Havre - Montivilliers (76)


number of children: 159

CHU de Nantes - CIC (44)
CHU d'Angers (49)
CH Le Mans (72)

Franche Comté

number of children: 39

CHU Jean Minoz - Besançon (25)


number of children: 721

Hôpital Necker-Cochin - CIC (75)
Hôpital Trousseau - Institut I-Motion (75)
CH Sud Francilien - Corbeil Essonnes (91)


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