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Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort

Guellec I, Brunet A, Lapillonne A, Taine M, Torchin H, Favrais G, Gascoin G, Simon L, Heude B, Scherdel P, Kayem G, Delorme P, Jarreau PH, Ancel PY.

Arch Dis Child. 2024 Feb 26:archdischild-2023-326336. doi: 10.1136/archdischild-2023-326336. Online ahead of print. PMID: 38408861


Neurodevelopment at age 5.5 years according to Ages & Stages Questionnaire at 2 years' corrected age in children born preterm: the EPIPAGE-2 cohort study

Charkaluk ML, Kana GD, Benhammou V, Guellec I, Letouzey M, Morgan AS, Nuytten A, Torchin H, Twilhaar S, Cambonie G, Marret S, Ancel PY, Pierrat V; Neurodevelopmental writing group of EPIPAGE-2.

Arch Dis Child Fetal Neonatal Ed. 2024 Feb 9:fetalneonatal-2023-325928. doi: 10.1136/archdischild-2023-325928. Online ahead of print. PMID: 38290830


Clinical Chorioamnionitis and Neurodevelopment at 5 Years of Age in Children Born Preterm: The EPIPAGE-2 Cohort Study

Salmon F, Kayem G, Maisonneuve E, Foix-L'Hélias L, Benhammou V, Kaminski M, Marchand-Martin L, Kana G, Subtil D, Lorthe E, Ancel PY, Letouzey M; EPIPAGE-2 Infectious diseases working group.

J Pediatr. 2024 Jan 17:113921. doi: 10.1016/j.jpeds.2024.113921. Online ahead of print. PMID: 38242316


Doxapram for apnoea of prematurity and neurodevelopmental outcomes at age 5-6 years

Tréluyer L, Zana-Taieb E, Jarreau PH, Benhammou V, Kuhn P, Letouzey M, Marchand-Martin L, Onland W, Pierrat V, Saade L, Ancel PY, Torchin H.

Arch Dis Child Fetal Neonatal Ed. 2024 Jan 16:fetalneonatal-2023-326170. doi: 10.1136/archdischild-2023-326170. Online ahead of print. PMID: 38228381


High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

Rozé JC, Bacchetta J, Lapillonne A, Boudred F, Picaud JC, Marchand-Martin L, Bruel-Tessoulin A, Harambat J, Biran V, Nuyt AM, Darmaun D, Ancel PY.

J Am Heart Assoc. 2023 Dec 29:e032804. doi: 10.1161/JAHA.123.032804. Online ahead of print. PMID: 38156453
Association between gut microbiota at 3.5 years of age and body mass index at 5 years: results from two French nationwide birth cohorts

Toubon G, Butel MJ, Rozé JC, Delannoy J, Ancel PY, Aires J, Charles MA.

Int J Obes (Lond). 2023 Dec 15. doi: 10.1038/s41366-023-01442-x. Online ahead of print. PMID: 38097759


Long-term neurological and neurodevelopmental outcome of neonatal listeriosis in France: a prospective, matched, observational cohort study

Charlier C, Barrault Z, Rousseau J, Kermorvant-Duchemin E, Meyzer C, Semeraro M, Fall M, Coulpier G, Leclercq A, Charles MA, Ancel PY, Lecuit M.

Lancet Child Adolesc Health. 2023 Oct 20:S2352-4642(23)00195-5. doi: 10.1016/S2352-4642(23)00195-5. Online ahead of print. PMID: 37871603


Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study (EPIPAGE-2)

Lortherm E, Marchand-Martin L, Letouzey M, Aubert AM, Pierrat V, Benhammou V, Delorme P, Marret S, Ancel PY, Goffinet F, L'hélias LF, Kayem G; EPIPAGE-2 Obstetric Writing Group.

Am J Obstet Gynecol. 2023 Oct 10:S0002-9378(23)00739-1. doi: 10.1016/j.ajog.2023.10.010. Online ahead of print. PMID: 37827270


Maternal health-related quality of life at 1 year after a preterm birth: role of socioeconomic status at birth

Benhammou V, Marchand-Martin L, Pierrat V, Charkaluk ML, Romito P, Kaminski M, Ancel PY, Saurel-Cubizolles MJ.

J Epidemiol Community Health. 2023 Sep 26:jech-2023-220591. doi: 10.1136/jech-2023-220591. Online ahead of print. PMID: 37752012


Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction: A Randomized Clinical Trial.

Gire C, Beltran Anzola A, Marret S, Foix L'Hélias L, Roze JC, Granier M, Patural H, Lecomte B, Guillois B, Souksi Medioni I, Bednarek Weirauch N, Claris O, Hascoët JM, Kuhn P, Zahed M, Boucekine M, Ancel PY, Arnaud C, Cambonie G, Dorriere Datin V; EPIREMED Study Group.

JAMA Netw Open. 2023 Sep 5;6(9):e2331988. doi: 10.1001/jamanetworkopen.2023.31988. PMID: 37676661


Pulmonary hypertension among preterm infants born at 22 through 32 weeks gestation in France: Prevalence, survival, morbidity and management in the EPIPAGE-2 cohort study.

Breinig S, Ehlinger V, Rozé JC, Storme L, Torchin H, Durrmeyer X, Cambonie G, Delacourt C, Jarreau PH, Berthomieu L, Brissaud O, Benhammou V, Gascoin G, Arnaud C, Ancel PY.

Early Hum Dev. 2023 Aug 3;184:105837. doi: 10.1016/j.earlhumdev.2023.105837. Online ahead of print. PMID: 37595540


Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model.

Diguisto C, Morgan AS, Foix L'Hélias L, Pierrat V, Ancel PY, Cohen JF, Goffinet F.

BJOG. 2023 Aug 17. doi: 10.1111/1471-0528.17633. Online ahead of print. PMID: 37592874


Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: the EPIPAGE-2 study.

Boileau P, Letouzey M, Morgan AS, Lorthe E, Kaminski M, Coquelin A, Azria E, Caeymaex L, Rouget F, Diguisto C, Claris O, Tosello B, Truffert P, Bétrémieux P, Benhammou V, Marchand-Martin L, Goffinet F, Ancel PY, Foix-L'Hélias L.

Acta Paediatr. 2023 Jul 4. doi: 10.1111/apa.16894. Online ahead of print. PMID: 37402152


Timing of antenatal corticosteroids and survival without neurological disabilities at 5½ years in children born before 35 weeks of gestation.

Guerini C, Goffinet F, Marchand-Martin L, Delorme P, Pierrat V, Ancel PY, Schmitz T.

Am J Obstet Gynecol. 2023 Jun 30:S0002-9378(23)00445-3. doi: 10.1016/j.ajog.2023.06.047. Online ahead of print. PMID: 37394223


Early Life Factors Influencing Children Gut Microbiota at 3.5 Years from Two French Birth Cohorts.

Toubon G, Butel MJ, Rozé JC, Nicolis I, Delannoy J, Zaros C, Ancel PY, Aires J, Charles MA.

Microorganisms. 2023 May 25;11(6):1390. doi: 10.3390/microorganisms11061390. PMID: 37374892


Neurodevelopment and healthcare utilisation at age 5-6 years in bronchopulmonary dysplasia: an EPIPAGE-2 cohort study.

Tréluyer L, Nuytten A, Guellec I, Jarreau PH, Benhammou V, Cambonie G, Truffert P, Marchand-Martin L, Ancel PY, Torchin H.

Arch Dis Child Fetal Neonatal Ed. 2023 Jun 23:fetalneonatal-2023-325376. doi: 10.1136/archdischild-2023-325376. Online ahead of print. PMID: 37364896


Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study.

Hoarau D, Tosello B, Blanc J, Lorthe E, Foix-L'Helias L, D'Ercole C, Winer N, Subtil D, Goffinet F, Kayem G, Resseguier N, Gire C; EPIPAGE2 Obstetric Writing Group*.

BJOG. 2023 Apr 17. doi: 10.1111/1471-0528.17460. Online ahead of print. PMID: 37069725


The interrelatedness of cognitive abilities in very preterm and full-term born children at 5.5 years of age: a psychometric network analysis approach.

Rapuc S, Pierrat V, Marchand-Martin L, Benhammou V, Kaminski M, Ancel PY, Twilhaar ES.

J Child Psychol Psychiatry. 2023 May 11. doi: 10.1111/jcpp.13816. Online ahead of print. PMID: 37165961


Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5.

Tréluyer L, Chevallier M, Jarreau PH, Baud O, Benhammou V, Gire C, Marchand-Martin L, Marret S, Pierrat V, Ancel PY, Torchin H.

Pediatrics. 2023 Apr 1;151(4):e2022059138. doi: 10.1542/peds.2022-059138. PMID: 36919442


Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children.

Gire C, Fournier N, Pirrello J, Marret S, Patural H, Flamant C, Pierrat V, Kaminski M, Ancel PY, Tosello B, Berbis J.

Children (Basel). 2023 Jan 25;10(2):209. doi: 10.3390/children10020209. PMID: 36832338


Survival and neurodevelopmental impairment of outborn preterm infants at 5.5 years of age: an EPIPAGE-2 prospective, matched study using multiple imputation.

Jones P, Marchand-Martin L, Desplanches T, Diguisto C, Fresson J, Goffinet F, Dauger S, Ancel PY, Morgan AS.BMJ Paediatr Open.

2022 Dec;6(1):e001619. doi: 10.1136/bmjpo-2022-001619.


Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants.

Le Ray I, Kuhn P, Letouzey M, Roué JM, Mitha A, Glorieux I, Foix-L'Hélias L, Marchand-Martin L, Ancel PY, Kaminski M, Pierrat V; Epipage 2 Neurodevelopmental care writing Group; EPIPAGE-2 Infectious diseases writing group.

Pediatr Res. 2022 Nov 14. doi: 10.1038/s41390-022-02383-3. Online ahead of print. PMID: 36376509.


Maternal pre-pregnancy obesity and offspring hyperactivity-inattention symptoms at 5 years in preterm and term children: a multi-cohort analysis.

Dow C, Lorthe E, Marchand-Martin L, Galera C, Tafflet M, Ancel PY, Charles MA, Heude B.

Sci Rep. 2022 Oct 28;12(1):18190. doi: 10.1038/s41598-022-22750-8. PMID: 36307528 Free PMC article.


Growth trajectory during the first 1000 days and later overweight in very preterm infants.

Simon L, Hadchouel A, Arnaud C, Frondas-Chauty A, Marret S, Flamant C, Darmaun D, Delacourt C, Marchand-Martin L, Ancel PY, Roze JC.

Arch Dis Child Fetal Neonatal Ed. 2022 Aug 25:fetalneonatal-2022-324321. doi: 10.1136/archdischild-2022-324321. Online ahead of print. PMID: 36008103


In-hospital Outcomes and Early Hemodynamic Management According to Echocardiography Use in Hypotensive Preterm Infants: A National Propensity-Matched Cohort Study.

Raschetti R, Torchin H, Marchand-Martin L, Gascoin G, Cambonie G, Brissaud O, Rozé JC, Storme L, Ancel PY, Mekontso-Dessap A, Durrmeyer X.

Front Cardiovasc Med. 2022 Jul 14;9:852666. doi: 10.3389/fcvm.2022.852666. eCollection 2022. PMID: 35911541


Very Preterm Children Gut Microbiota Comparison at the Neonatal Period of 1 Month and 3.5 Years of Life.

Toubon G, Butel MJ, Rozé JC, Lepage P, Delannoy J, Ancel PY, Charles MA, Aires J; EPIFLORE Study Group.

Front Microbiol. 2022 Jul 22;13:919317.


Longitudinal impact of psychosocial status on children's mental health in the context of COVID-19 pandemic restrictions.

Moulin F, Bailhache M, Monnier M, Thierry X, Vandentorren S, Cote SM, Falissard B, Simeon T, Geay B, Marchand L, Dufourg MN, Ancel PY, Charles MA, Rouquette A, Melchior M, Galera C, group SsEur.

Child Adolesc Psychiatry 2022 2022 Jun 2:1–10.


Neurodevelopment at 5 years of age for preterm-born children according to mode of conception: a cohort study.

Verhaeghe C, Marchand-Martin L, Kaminski M, Gascoin G, Foix L'hélias L, Ancel PY, Bouet PE, Morgan AS.

Am J Obstet Gynecol. 2022 Jun 4:S0002-9378(22)00437-9. doi: 10.1016/j.ajog.2022.05.062. Online ahead of print. PMID: 35671779


Ophthalmological Impairments at Five and a Half Years after Preterm Birth: EPIPAGE-2 Cohort Study.

Chapron T, Pierrat V, Caputo G, Letouzey M, Kermorvant-Duchemin E, Abdelmassih Y, Beaumont W, Barjol A, Le Meur G, Benhammou V, Marchand-Martin L, Ancel PY, Torchin H.

J Clin Med. 2022 Apr 11;11(8):213.


Emotional and attention-deficit/hyperactivity disorder symptoms of preterm vs. full-term children during COVID-19 pandemic restrictions.

Bailhache M, Monnier M, Moulin F, Thierry X, Vandentorren S, Côté SM, Falissard B, Simeon T, Geay B, Marchand L, Dufourg MN, Charles MA, Ancel PY, Melchior M, Rouquette A, Galera C; SAPRIS study group.

Pediatr Res. 2022 Mar 30. doi: 10.1038/s41390-022-02037-4. Online ahead of print.
Risk Factors for High-arched Palate and Posterior Crossbite at Age 5 in Children Born Very Preterm: EPIPAGE-2 Cohort Study.

Herrera S, Pierrat V, Kaminski M, Benhammou V, Marchand-Martin L, AS Morgan, Le Norcy E, Ancel PY, Germa A. Frontiers dans la section General Pediatrics and Pediatric Emergency Care

Front Pediatr. 2022 Apr 15;10:784911. doi: 10.3389/fped.2022.784911. eCollection 2022. PMID: 35498807
Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: perinatal and 2-year outcomes in the EPIPAGE-2 cohort.

Lorthe E, Letouzey M, Torchin H, Foix L'helias L, Gras-Le Guen C, Benhammou V, Boileau P, Charlier C, Kayem G; EPIPAGE-2 Obstetric Writing Group.

BJOG. 2021 Dec 26. doi: 10.1111/1471-0528.17081.
Early antibiotic exposure and adverse outcomes in very preterm infants at low risk of early-onset sepsis: the EPIPAGE-2 cohort study.

Letouzey M, Lorthe E, Marchand-Martin L, Kayem G, Charlier C, Butin M, Mitha A, Kaminski M, Benhammou V, Ancel PY, Boileau P, Foix-L'Hélias L; + EPIPAGE-2 Infectious diseases working group.

J Pediatr. 2021 Dec 20:S0022-3476(21)01223-3. doi: 10.1016/j.jpeds.2021.11.075. Online ahead of print. PMID: 34942178.
Children’s well-being and intra-household family relationships during the first COVID-19 lockdown in France.

Pailhé A., Panico L., Solaz A., & SAPRIS study group.

Journal of Family Research, 2021, 1 32. https://doi.org/10.20377/jfr-718
Bronchopulmonary Dysplasia and Risk of Developmental Delay: An EPIPAGE-2 Cohort Study.

Tréluyer L, Jarreau PH, Marchand-Martin L, Benhammou V, Nuytten A, Berquin P, Marret S, Pierrat V, Ancel PY, Torchin H.

Neonatology. 2021 Dec 8:1-5. doi: 10.1159/000520451. Online ahead of print. PMID: 34879383.
Association Between Early Amino Acid Intake and Full-Scale IQ at Age 5 Years Among Infants Born at Less Than 30 Weeks' Gestation.

Rozé JC, Morel B, Lapillonne A, Marret S, Guellec I, Darmaun D, Bednarek N, Moyon T, Marchand-Martin L, Benhammou V, Pierrat V, Flamant C, Gascoin G, Mitanchez D, Cambonie G, Storme L, Tosello B, Biran V, Claris O, Picaud JC, Favrais G, Beuchée A, Loron G, Gire C, Durrmeyer X, Gressens P, Saliba E, Ancel PY; Nutrition EPIPAGE-2 Study Group and the EPIRMEX Study Group.

JAMA Netw Open. 2021 Nov 1;4(11):e2135452. doi: 10.1001/jamanetworkopen.2021.35452. PMID: 34846527.
Children's mental and behavioral health, schooling, and socioeconomic characteristics during school closure in France due to COVID-19: the SAPRIS project.

Monnier M, Moulin F, Thierry X, Vandentorren S, Côté S, Barbosa S, Falissard B, Plancoulaine S, Charles MA, Simeon T, Geay B, Marchand L, Ancel PY, Melchior M, Rouquette A; SAPRIS study group, Galera C.

Sci Rep. 2021 Nov 17;11(1):22373. doi: 10.1038/s41598-021-01676-7. PMID: 34789783
Association of Continuous Opioids and/or Midazolam During Early Mechanical Ventilation with Survival and Sensorimotor Outcomes at Age 2 Years in Premature Infants: Results from the French Prospective National EPIPAGE 2 Cohort.

Tristan MA, Martin-Marchand L, Roué JM, Anand KJS, Pierrat V, Tourneux P, Kuhn P, Milesi C, Benhammou V, Ancel PY, Carbajal R, Durrmeyer X.

J Pediatr. 2021 May;232:38-47.e8. doi: 10.1016/j.jpeds.2020.12.069. Epub 2021 Jan 1. PMID: 33395567.
Profiles of Functioning in 5.5-Year-Old Very Preterm Born Children in France: The EPIPAGE-2 Study.

Twilhaar ES, Pierrat V, Marchand-Martin L, Benhammou V, Kaminski M, Ancel PY.

J Am Acad Child Adolesc Psychiatry. 2021 Sep 7:S0890-8567(21)01366-6.


Mortality and significant neurosensory impairment in preterm infants: an international comparison.

Chevallier M, Debillon T, Darlow BA, Synnes AR, Pierrat V, Hurrion E, Yang J, Ego A, Ancel PY, Lui K, Shah PS, Luu TM; Australian and New Zealand Neonatal Network (ANZNN); Canadian Neonatal Network (CNN); Canadian Neonatal Follow-Up Network (CNFUN); Etude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE-2) Investigators.

Arch Dis Child Fetal Neonatal Ed. 2021 Sep 11:fetalneonatal-2021-322288.


Birth outcomes between 22 and 26 weeks' gestation in national population-based cohorts from Sweden, England and France.

Morgan AS, Zeitlin J, Källén K, Draper ES, Maršál K, Norman M, Serenius F, van Buuren S, Johnson S, Benhammou V, Pierrat V, Kaminski M, Foix L'Helias L, Ancel PY, Marlow N.

Acta Paediatr. 2021 Sep 1.


A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit.

Gire C, Beltran Anzola A, Kaminski M, Baumstarck K, Ancel PY, Berbis J; for EPIREMED-Study Group.

BMC Pediatr. 2021 Sep 13;21(1):402.


Early discharge and hospital-assisted home care is associated with better neurodevelopmental outcome in preterm infants.

Losbar JL, Montjaux N, Ehlinger V, Germany L, Arnaud C, Tscherning C.

Early Hum Dev. 2021 Oct;161:105451.


Cohort Profile: The Etude Epidemiologique sur les Petits Ages Gestationnels-2 (EPIPAGE-2) preterm birth cohort.

Lorthe E, Benhammou V, Marchand-Martin L, Pierrat V, Lebeaux C, Durox M, Goffinet F, Kaminski M, Ancel PY.

Int J Epidemiol. 2021 Jun 24.


Risk factors for very preterm delivery out of a level III maternity unit: The EPIPAGE-2 cohort study.

Desplanches T, Morgan AS, Jones P, Diguisto C, Zeitlin J, Martin-Marchand L, Benhammou V, Lecomte B, Rozé JC, Truffert P, Ancel PY, Sagot P, Roussot A, Fresson J, Blondel B.

Paediatr Perinat Epidemiol. 2021 May 6.


Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study.

Pierrat V, Marchand-Martin L, Marret S, Arnaud C, Benhammou V, Cambonie G, Debillon T, Dufourg MN, Gire C, Goffinet F, Kaminski M, Lapillonne A, Morgan AS, Rozé JC, Twilhaar S, Charles MA, Ancel PY; EPIPAGE-2 writing group.

BMJ. 2021 Apr 28;373:n741. doi: 10.1136/bmj.n741.


Machine-Learning vs. Expert-Opinion Driven Logistic Regression Modelling for Predicting 30-Day Unplanned Rehospitalisation in Preterm Babies: A Prospective, Population-Based Study (EPIPAGE 2).

Reed RA, Morgan AS, Zeitlin J, Jarreau PH, Torchin H, Pierrat V, Ancel PY, Khoshnood B.

Front Pediatr.2021 Feb 3;8:585868. doi: 10.3389/fped.2020.585868. eCollection 2020.


Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study.

Letouzey M, Foix-L’Hélias L, Torchin H, Mitha A, Morgan AS, Zeitlin J, Kayem G, Maisonneuve E, Delorme P, Khoshnood B, Kaminski M, Ancel PY, Boileau P, Lorthe E and The EPIPAGE-2 Working Group on Infections.

Pediatr Res. 2021 Feb 24;1-9. doi: 10.1038/s41390-021-01411-y. Online ahead of print. PMID: 33627822.


Screening for Retinopathy of Prematurity in Very Preterm Children: The EPIPAGE-2Cohort Study.

Chapron T, Caputo G, Pierrat V, Kermorvant E, Barjol A, Durox M, Ancel PY, Torchin H.

JNeonatology. 2021 Feb 11:1-10.doi: 10.1159/000513225.


Occurrence and severity of acute respiratory infections during the first year among very preterm infants: an Epipage-2cohort analysis.

Charkaluk ML, Rousseau J, Dehouck-Vallois M, Jarreau PH, Nuytten A, Treluyer L, Ancel PY, Torchin H.

J Pediatr. 2021 Feb 1. doi: 10.1007/s00431-021-03956-w.


Thresholds of glycemia, insulin therapy, and risk for severe retinopathy in premature infants: A cohort study

Kermorvant-Duchemin E, Le Meur G , Plaisant F, Marchand-Martin L, Flamant C, Porcher R, Lapillonne A, Chemtob S, Claris O, Ancel PY, Rozé JC.

PLoS Med. 2020 Dec 11;17(12):e1003477. doi: 10.1371/journal.pmed.1003477.
Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes.

Rozé JC, Ancel PY, Marchand-Martin L, Rousseau C, Montassier E, Monot C, Le Roux K, Butin M, Resche-Rigon M, Aires J, Neu J, Lepage P, Butel MJ;EPIFLORE Study Group.

JAMA Netw Open. 2020 Sep 1;3(9):e2018119. doi: 10.1001/jamanetworkopen.2020.18119.


Factors associated with non-nutritive sucking habits at 2 years of age among very preterm children: EPIPAGE-2 cohort study.

Herrera S, Pierrat V, Kaminski M, Benhammou V, Bonnet AL, Ancel PY, Germa A.

Paediatr Perinat Epidemiol. 2020 Oct 5. doi: 10.1111/ppe.12725.


Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population-based cohort study.

Blanc J, Rességuier N, Lorthe E, Goffinet F, Sentilhes L, Auquier P, Tosello B, d'Ercole C.

BJOG. 2020 Sep 15. doi: 10.1111/1471-0528.16499. Online ahead of print.


Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study.

Maisonneuve E, Lorthe E, Torchin H, Delorme P, Devisme L, L'Hélias LF, Marret S, Subtil D, Bodeau-Livinec F, Pierrat V, Sentilhes L, Goffinet F, Ancel PY, Kayem G; EPIPAGE-2 Obstetric writing group.

Pediatr. 2020 Jul;222:71-78.e6. doi: 10.1016/j.jpeds.2020.03.021.


Variations in patterns of care across neonatal units and their associations with outcomes in very preterm infants: the French EPIPAGE-2 cohort study.

Pierrat V, Burguet A, Marchand-Martin L, Cambonie G, Coquelin A, Roze JC, Durox M, Guillois B, Morgan AS, Kaminski M; Neurodevelopmental care study group of EPIPAGE-2.

BMJ Open. 2020 Jun 22;10(6):e035075. doi: 10.1136/bmjopen-2019-035075.


Planned delivery route and outcomes of cephalic singletons born spontaneously at 24-31 weeks' gestation: The EPIPAGE-2 cohort study.

Gaudineau A, Lorthe E, Quere M, Goffinet F, Langer B, Le Ray I, Subtil D.

Acta Obstet Gynecol Scand. 2020 Jun 18. doi: 10.1111/aogs.13939.


Neurodevelopment at age 2 and umbilical artery Doppler in cases of preterm birth after prenatal hypertensive disorder or suspected fetal growth restriction: the EPIPAGE 2 prospective population-based cohort study.

Delorme P, Kayem G, Lorthe E, Sentilhes L, Zeitlin J, Subtil D, Rozé JC, Vayssière C, Durox M, Ancel PY, Pierrat V, Goffinet F; EPIPAGE2 Obstetrical Study Group.

Ultrasound Obstet Gynecol. 2020 Mar 25. doi: 10.1002/uog.22025.


Breast milk feeding of preterm infants in France. What have we learned from the EPIPAGE studies ?

Mitha A, Pierrat V.

Arch Pediatr. 2020 Feb;27(2):63-65. doi: 10.1016/j.arcped.2019.12.004. Epub 2020 Jan 18.


The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study.

Tosello B, Garbi A, Blanc J, Lorthe E, Foix-L'Hélias L, D'Ercole C, Winer N, Subtil D, Goffinet F, Kayem G, Resseguier N, Gire C.

EPIPAGE-2 Obstetric Writing Group.BJOG. 2020 Feb 11. doi: 10.1111/1471-0528.16170.


Maternal cumulative exposure to extremely low frequency electromagnetic fields, prematurity and small for gestational age: a pooled analysis of two birth cohorts.

Migault L, Garlantézec R, Piel C, Marchand-Martin L, Orazio S, Cheminat M, Zaros C, Carles C, Cardis E, Ancel PY, Charles MA, de Seze R, Baldi I, Bouvier G.

Occup Environ Med. 2020 Jan;77(1):22-31. doi: 10.1136/oemed-2019-105785.


Intensity of perinatal care for extremely preterm babies and outcomes at a higher gestational age: evidence from the EPIPAGE-2 cohort study.

Morgan AS, Khoshnood B, Diguisto C, Foix L'Helias L, Marchand-Martin L, Kaminski M, Zeitlin J, Bréart G, Goffinet F, Ancel PY.

BMC Pediatr. 2020 Jan 7;20(1):8. doi: 10.1186/s12887-019-1856-1
Assessing the risk of early unplanned rehospitalisation in preterm babies: EPIPAGE 2 study.

Reed RA, Morgan AS, Zeitlin J, Jarreau PH, Torchin H, Pierrat V, Ancel PY, Khoshnood B.

BMC Pediatr. 2019 Nov 21;19(1):451. doi: 10.1186/s12887-019-1827-6.
Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies.

Godeluck A, Gérardin P, Lenclume V, Mussard C, Robillard PY, Sampériz S, Benhammou V, Truffert P, Ancel PY, Ramful D.

BMC Pediatr. 2019 Oct 17;19(1):360. doi: 10.1186/s12887-019-1700-7.
The impact of neonatal unit policies on breast milk feeding at discharge of moderate preterm infants: The EPIPAGE-2 cohort study.

Mitha A, Piedvache A, Khoshnood B, Fresson J, Glorieux I, Roué JM, Blondel B, Durox M, Burguet A, Ancel PY, Kaminski M, Pierrat V.

Matern Child Nutr. 2019 Oct;15(4):e12875. doi: 10.1111/mcn.12875. Epub 2019 Aug 13.
Prenatal parental involvement in decision for delivery room management at 22-26 weeks of gestation in France - The EPIPAGE-2 Cohort Study.

Levaillant C, Caeymaex L, Béhal H, Kaminski M, Diguisto C, Tosello B, Azria E, Claris O, Bétrémieux P, Foix L'Hélias L, Truffert P; EPIPAGE 2 Extreme Prematurity Group.

PLoS One. 2019 Aug 29;14(8):e0221859. doi: 10.1371/journal.pone.0221859. eCollection 2019.
Volume of Neonatal Care and Survival without Disability at 2 Years in Very Preterm Infants: Results of a French National Cohort Study.

Desplanches T, Blondel B, Morgan AS, Burguet A, Kaminski M, Lecomte B, Marchand-Martin L, Rozé JC, Sagot P, Truffert P, Zeitlin J, Ancel PY, Fresson J.

J Pediatr. 2019 Jul 4. pii: S0022-3476(19)30693-6. doi: 10.1016/j.jpeds.2019.06.001.

Perceived maternal information on premature infant's pain during hospitalization: the French EPIPAGE-2 national cohort study.
Pierrat V, Marchand-Martin L, Durrmeyer X, Vasante L, Burguet A, Cambonie G, Kuhn P, Datin-Dorrière V, Durox M, Kaminski M, Carbajal R, Ancel PY; Neurodevelopmental Care Study Group of EPIPAGE -2.

Pediatr Res. 2019 May 13. doi: 10.1038/s41390-019-0422-8.

Premedication practices for delivery room intubations in premature infants in France: Results from the EPIPAGE 2 cohort study.
Walter-Nicolet E, Courtois E, Milesi C, Ancel PY, Beuchée A, Tourneux P, Benhammou V, Carbajal R, Durrmeyer X.

PLoS One. 2019 Apr 10;14(4):e0215150. doi: 10.1371/journal.pone.0215150. eCollection 2019.

Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study. Chevallier M, Ancel PY, Torchin H, Marchand-Martin L, Lorthe E, Truffert P, Jarreau PH, Roze JC, Pierrat V, Marret S, Baud O, Benhammou V, Ego A, Debillon T.PLoS One. 2019 Apr 4;14(4):e0214232. doi: 10.1371/journal.pone.0214232. eCollection 2019.

Association of Language Skills with Other Developmental Domains in Extremely, Very, and Moderately Preterm Children: EPIPAGE 2 Cohort Study.

Charkaluk ML, Rousseau J, Benhammou V, Datin-Dorrière V, Flamant C, Gire C, Kern S, Pierrat V, Kaminski M, Marret S.

J Pediatr. 2019 May;208:114-120.e5. doi: 10.1016/j.jpeds.2018.12.007. Epub 2019 Mar 14.
A population-based comparison of preterm neonatal deaths (22-34 gestational weeks) in France and Ontario: a cohort study.

Wang D, Yasseen AS 3rd, Marchand-Martin L, Sprague AE, Graves E, Goffinet F, Walker M, Ancel PY, Lacaze-Masmonteil T.

CMAJ Open. 2019 Mar 14;7(1):E159-E166. doi: 10.9778/cmajo.20180199. Print 2019 Jan-Mar.
Unit policies and breast milk feeding at discharge of very preterm infants: The EPIPAGE-2 cohort study.

Mitha A, Piedvache A, Glorieux I, Zeitlin J, Roué JM, Blondel B, Durox M, Burguet A, Kaminski M, Ancel PY, Pierrat V; EPIPAGE-2 Neurodevelopmental Care Writing Group.

Paediatr Perinat Epidemiol. 2019 Jan;33(1):59-69. doi: 10.1111/ppe.12536.
Association of Intraventricular Hemorrhage and Death With Tocolytic Exposure in Preterm Infants.

Pinto Cardoso G, Houivet E, Marchand-Martin L, Kayem G, Sentilhes L, Ancel PY, Lorthe E, Marret S; EPIPAGE-2 Working Group.

JAMA Netw Open. 2018 Sep 7;1(5):e182355. doi: 10.1001/jamanetworkopen.2018.2355.

Association between gestational age and severe maternal morbidity and mortality of preterm cesarean delivery: a population-based cohort study.
Blanc J, Resseguier N, Goffinet F, Lorthe E, Kayem G, Delorme P, Vayssière C, Auquier P, D'Ercole C.
Am J Obstet Gynecol. 2019 Apr;220(4):399.e1-399.e9. doi: 10.1016/j.ajog.2019.01.005. Epub 2019 Jan 8.

Indications leading to termination of pregnancy between 22+0 and 31+6 weeks of gestational age in France: A population-based cohort study.
Monier I, Lelong N, Ancel PY, Benachi A, Khoshnood B, Zeitlin J, Blondel B.
Eur J Obstet Gynecol Reprod Biol. 2019 Feb;233:12-18. doi: 10.1016/j.ejogrb.2018.11.021. Epub 2018 Dec 3.

Planned Mode of Delivery of Preterm Twins and Neonatal and 2-Year Outcomes.

Sentilhes L, Lorthe E, Marchand-Martin L, Marret S, Ancel PY, Delorme P, Goffinet F, Quere M, Kayem G; Etude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE) 2 Obstetric Writing Group.

Obstet Gynecol. 2019 Jan;133(1):71-80. doi: 10.1097/AOG.0000000000003004.


Intensity of perinatal care, extreme prematurity and sensorimotor outcome at 2 years corrected age: evidence from the EPIPAGE-2 cohort study.

Diguisto C, Marchand-Martin L, Kaminski M, Khoshnood B, Zeitlin J, Bréart G, Durrmeyer X, Goffinet F, Ancel PY

BMC Med. 2018 Dec 5;16(1):227.


Neonatal Outcomes in Extremely Preterm Newborns Admitted to Intensive Care after No Active Antenatal Management: A Population-Based Cohort Study.

Diguisto C, Foix L'Helias L, Morgan AS, Ancel PY, Kayem G, Kaminski M, Perrotin F, Khoshnood B, Goffinet F.

J Pediatr. 2018 Dec;203:150-155.

Planned delivery route of preterm breech singletons and neonatal and 2-year outcomes: a population-based cohort study. Lorthe E, Sentilhes L, Quere M, Lebeaux C, Winer N, Torchin H, Goffinet F, Delorme P, Kayem G; EPIPAGE-2 Obstetric Writing Group.
BJOG. 2018 Sep 14. doi: 10.1111/1471-0528.15466.

Comparison of the Hadlock and INTERGROWTH 21st formulas for calculating estimated fetal weight in a preterm population in France.

Monier I, Ego A, Benachi A, Ancel PY, Goffinet F, Zeitlin J.

Am J Obstet Gynecol. 2018 Aug 14. pii: S0002-9378(18)30664-1. doi: 10.1016/j.ajog.2018.08.012.
Preterm premature rupture of membranes at 22-25 weeks' gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2).

Lorthe E, Torchin H, Delorme P, Ancel PY, Marchand-Martin L, Foix-L'Hélias L, Benhammou V, Gire C, d'Ercole C, Winer N, Sentilhes L, Subtil D, Goffinet F, Kayem G.

Am J Obstet Gynecol. 2018 Sep;219(3):298.e1-298.e14. doi: 10.1016/j.ajog.2018.05.029. Epub 2018 May 29.
Palivizumab administration in preterm infants in France: EPIPAGE-2 cohort study.

Torchin H, Rousseau J, Marchand-Martin L, Truffert P, Jarreau PH, Ancel PY.

Arch Pediatr. 2018 Feb;25(2):89-94. doi: 10.1016/j.arcped.2017.12.009. Epub 2018 Feb 1.
Mother-infant interaction assessment at discharge and at 6 months in a French cohort of infants born very preterm: The OLIMPE study.

Cambonie G, Muller JB, Ehlinger V, Roy J, Guédeney A, Lebeaux C, Kaminski M, Alberge C, Denizot S, Ancel PY, Arnaud C; OLIMPE study writing group.

PLoS One. 2017 Dec 7;12(12):e0188942. doi: 10.1371/journal.pone.0188942. eCollection 2017.
Efficacity of antenatal corticosteroids in very preterm twins: the EPIPAGE-2 cohort study.

Palas D, Ehlinger V, Alberge C, Truffert P, Kayem G, Goffinet F, Ancel PY, Arnaud C, Vayssière C.

BJOG. 2018 Aug;125(9):1164-1170. doi: 10.1111/1471-0528.15014. Epub 2017 Dec 14.
Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study.

Pierrat V, Marchand-Martin L, Arnaud C, Kaminski M, Resche-Rigon M, Lebeaux C, Bodeau-Livinec F, Morgan AS, Goffinet F, Marret S, Ancel PY; EPIPAGE-2 writing group.

BMJ. 2017 Aug 16;358:j3448. doi: 10.1136/bmj.j3448.
Providing active antenatal care depends on the place of birth for extremely preterm births: the EPIPAGE 2 cohort study.

Diguisto C, Goffinet F, Lorthe E, Kayem G, Roze JC, Boileau P, Khoshnood B, Benhammou V, Langer B, Sentilhes L, Subtil D, Azria E, Kaminski M, Ancel PY, Foix-L'Hélias L.

Arch Dis Child Fetal Neonatal Ed. 2017 Nov;102(6):F476-F482. doi: 10.1136/archdischild-2016-312322. Epub 2017 Jun 30.
Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants.

Rozé JC, Ancel PY, Lepage P, Martin-Marchand L, Al Nabhani Z, Delannoy J, Picaud JC, Lapillonne A, Aires J, Durox M, Darmaun D, Neu J, Butel MJ; Nutrition EPIPAGE 2 study group and the EPIFLORE Study Group.

AM J Clin Nutr. 2017 Sep;106(3):821-830. doi: 10.3945/ajcn. 117. 152967. Epub 2017 Jun 28.
Incidence and risk factors of caesarean section in preterm breech births: A population-based cohort study.

Lorthe E, Quere M, Sentilhes L, Delorme P, Kayem G.

Eur J Obstet Gynecol Reprod Biol. 2017 May;212:37-43. doi: 10.1016/j.ejogrb.2017.03.019. Epub 2017 Mar 10.
Abstention or intervention for isolated hypotension in the first 3 days of life in extremely preterm infants: association with short-term outcomes in the EPIPAGE 2 cohort study.

Durrmeyer X, Marchand-Martin L, Porcher R, Gascoin G, Roze JC, Storme L, Favrais G, Ancel PY, Cambonie G; Hemodynamic EPIPAGE 2 Study Group.

Arch Dis Child Fetal Neonatal Ed. 2017 Mar 16. pii: fetalneonatal-2016-312104. doi: 10.1136/archdischild-2016-312104.
Gestational age at diagnosis of early-onset fetal growth restriction and impact on management and survival: a population-based cohort study.

Monier I, Ancel PY, Ego A, Guellec I, Jarreau PH, Kaminski M, Goffinet F, Zeitlin J; EPIPAGE 2 Study Group.

BJOG. 2017 Mar 7. doi: 10.1111/1471-0528.14555.
Fetal and neonatal outcomes of preterm infants born before 32 weeks of gestation according to antenatal vs postnatal assessments of restricted growth.

Monier I, Ancel PY, Ego A, Jarreau PH, Lebeaux C, Kaminski M, Goffinet F, Zeitlin J; EPIPAGE 2 Study Group.

Am J Obstet Gynecol. 2017 May;216(5):516.e1-516.e10. doi: 10.1016/j.ajog.2017.02.001. Epub 2017 Feb 8.
Policy of feeding very preterm infants with their mother's own fresh expressed milk was associated with a reduced risk of bronchopulmonary dysplasia.

Dicky O, Ehlinger V, Montjaux N, Gremmo-Féger G, Sizun J, Rozé JC, Arnaud C, Casper C; EPIPAGE 2 Nutrition Study Group; EPINUTRI Study Group.

Acta Paediatr. 2017 May;106(5):755-762. doi: 10.1111/apa.13757. Epub 2017 Feb 28.
Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants. Results of the EPIPAGE 2 cohort study.

Chevallier M, Debillon T, Pierrat V, Delorme P, Kayem G, Durox M, Goffinet F, Marret S, Ancel PY; Neurodevelopment EPIPAGE 2 Writing Group.

AM J Obstet Gynecol. 2017 Jan 16. pii: S0002-9378(17)30102-3. doi: 10.1016/j.ajog.2017.01.002.
Impact of Latency Duration on the Prognosis of Preterm Infants after Preterm Premature Rupture of Membranes at 24 to 32 Weeks' Gestation: A National Population-Based Cohort Study.

Lorthe E, Ancel PY, Torchin H, Kaminski M, Langer B, Subtil D, Sentilhes L, Arnaud C, Carbonne B, Debillon T, Delorme P, D'Ercole C, Dreyfus M, Lebeaux C, Galimard JE, Vayssiere C, Winer N, L'Helias LF, Goffinet F, Kayem G.

J Pediatr. 2017 Jan 9. pii: S0022-3476(16)31382-8.doi: 10.1016/j.jpeds.2016.11.074.
Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort

Torchin H, Lorthe E, Goffinet F, Kayem G, Subtil D, Truffert P, Devisme L, Benhammou V, Jarreau PH, Ancel PY

J Pediatr. 2017 Aug;187:98-104.


Tocolysis after preterm premature rupture of membranes and neonatal outcome: a propensity-score analysis

Lorthe E, Goffinet F, Marret S, Vayssiere C, Flamant C, Quere M, Benhammou V, Ancel PY, Kayem G

Am J Obstet Gynecol. 2017. PMID: 28412086 


Impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in preterm infants: A literature review

Maisonneuve E, Ancel PY, Foix-L'Hélias L, Marret S, Kayem G

J Gynecol Obstet Hum Reprod. 2017. PMID: 28643657 Review. 


Delivery room deaths of extremely preterm babies: an observational study.

Durrmeyer X, Scholer-Lascourrèges C, Boujenah L, Bétrémieux P, Claris O, Garel M, Kaminski M, Foix-L'Helias L, Caeymaex L; EPIPAGE-2 Extreme Prematurity Writing Group.

Arch Dis Child Fetal Neonatal Ed. 2016 Aug 16. pii: fetalneonatal-2016-310718. doi: 10.1136/archdischild-2016-310718.
Translating Neurodevelopmental Care Policies Into Practice: The Experience of Neonatal ICUS in France- The EPIPAGE-2 Cohort Study.

Pierrat V, Coquelin A, Cuttini M, Khoshnood B, Glorieux I, Claris O, Durox M, Kaminski M, Ancel PY, Arnaud C; EPIPAGE-2 Neurodevelopmental Care Writing Group.

Pediatr Crit Care Med. 2016 Oct;17(10):957-967.
Complications placentaires et dysplasie broncho-pulmonaire : la cohorte EPIPAGE 2.

Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study.

Torchin H, Ancel PY, Goffinet F, Hascoët JM, Truffert P, Tran D, Lebeaux C, Jarreau PH.

Pediatrics. 2016 Mar;137(3):1-10. doi: 10.1542/peds.2015-2163.
Prise en charge des extrêmes prématurés en salle de naissance : l'étude EPIPAGE 2.

Delivery room management of extremely preterm infants: the EPIPAGE-2 study.

Perlbarg J, Ancel PY, Khoshnood B, Durox M, Boileau P, Garel M, Kaminski M, Goffinet F, Foix-L'Hélias L; Epipage-2 Ethics group.

Arch Dis Child Fetal Neonatal Ed. 2016 Feb 2. pii: fetalneonatal-2015-308728. doi: 10.1136/archdischild-2015-308728.
Cause de prématurité, facteur pronostic de mortalité.

Cause of Preterm Birth as a Prognostic Factor for Mortality.

Delorme P, Goffinet F, Ancel PY, Fois-L'Hélias L, Langer B, Lebeaux C, Marchand LM, Zeitlin J, Ego A, Arnaud C, Vayssiere C, Lorthe E, Durrmeyer X, Sentilhes L, Subtil D, Debillon T, Winer N, Kaminski M, D'Ercole C, Dreyfus M, Carbonne B, Kayem G.

Obstet Gynecol. 2016 Jan;127(1):40-8. doi: 10.1097/AOG.0000000000001179.
Epidémiologie de la prématurité : prévalence, évolution, devenir des enfants.

Epidemiology of preterm birth: Prevalence, recent trends, short-and long-term outcomes.

Torchin H, Ancel PY, Jarreau PH, Goffinet F.

J Gynecol Obstet Biol Reprod (Paris). 2015 Oct;44(8):723-31. doi: 10.1016/j.jgyn.2015.06.010. Epub 2015 Jul 2.
Association entre dépistage précoce de la persistance du canal artériel et mortalité hospitalière chez les extrêmes prématurés.

Association Between Early Screening for Patent Ductus Arteriosus and In-Hospital Mortality Among Extremely Preterm Infants.

Rozé JC, Cambonie G, Marchand-Martin L, Gournay V, Durrmeyer X, Durox M, Storme L, Porcher R, Ancel PY; Hemodynamic EPIPAGE 2 Study Group.

JAMA. 2015 Jun 23-30;313(24):2441-8. doi: 10.1001/jama.2015.6734.
Contexte social des naissances prématurées en France en 2011 et impact sur le devenir à court terme : cohorte EPIPAGE 2.

Social context of preterm delivery in France in 2011 and impact on short-term health outcomes: the EPIPAGE 2 cohort study.

Germany L, Saurel-Cubizolles MJ, Ehlinger V, Napoletano A, Alberge C, Guyard-Boileau B, Pierrat V, Genolini C, Ancel PY, Arnaud C; EPIPAGE Study Group.

JAMA Paediatr Perinat Epidemiol. 2015 May;29(3):184-95. doi: 10.1111/ppe.12189. Epub 2015 Apr 5.
Survie et morbidité des enfants prématurés nés entre 22 et 34 semaines d'aménorrhée en France en 2011 : les résultats de l'étude de cohorte EPIPAGE 2.

Survival and morbidity of preterm children born at 22 trough 34 weeks' gestation in France in 2011 : Results of the EPIPAGE 2 cohort study.

Pierre-Yves Ancel, PHD ; François Goffinet, PHD ; EPIPAGE 2 Writing Group.

JAMA Pediatr. 2015 Jan 26. doi: 10.1001/jamapediatrics.2014.3351.
EPIPAGE 2 : étude de cohorte des enfants prématurés en France en 2011 (protocole de l'étude)

EPIPAGE 2 : a preterm birth cohort in France in 2011 (study protocol)

Ancel PY, Goffinet F; EPIPAGE 2 Writing Group.

BMC Pediatr. 2014 Apr 9;14:97. doi: 10.1186/1471-2431-14-97.